X-Chem, Inc. is a privately-owned drug discovery, science and technology company based in Waltham, Massachusetts. As pioneer of DNA-encoded chemical library (DEL) technology, the company’s mission is to leverage its market-leading DEL platform to discover small molecule leads against high-value therapeutic targets.
DEL technology allows X-Chem’s partners to rapidly screen hundreds of billions of novel lead-like small molecule compounds simultaneously, and easily identify hits with desired potency, selectivity, mode of action, and attractive physicochemical properties.
X-Chem delivers innovative drug discovery solutions to biotech and pharmaceutical companies that need access to cutting edge scientific expertise to support an increasingly challenging drug discovery process. X-Chem differentiates itself thought the design and synthesis of next generation lead-like DEL libraries, novel approaches to DEL screening based on over a decade of experience screening hundreds of targets, and proprietary analysis techniques that take advantage of advanced computation approaches.
Working with over 50 biopharma companies — including 10 of the top 20 — X-Chem wields a vast index of molecules and proprietary tagging approaches. This reach enables drug developers to investigate a hugely diverse range of molecules that hold enormous potential. The success rate in identifying functional hits against challenging targets is 80% and X-Chem has licensed 85 programs.
X-Chem’s versatile technology is proven in projects spanning 30 target classes. These include challenging objectives such as protein-protein interactions (PPI), bacterial targets, ubiquitin ligases, epigenetic targets and G protein-coupled receptors (GPCR).
X-Chem has established partnerships with AbbVie, Alexion, Almirall, Bristol-Myers Squibb, AstraZeneca, Bayer, Department of Defense/Harvard, Gilead, Janssen, Maruho, MD Anderson Cancer Center, Ono, Orexia, Otsuka, Pfizer, Roche, Sanofi, Taiho Pharma, Vertex, and many other leading pharmaceutical companies, biotechnology organizations, and academic centers.
For further information please visit the X-Chem website.